QuestionAugust 17, 2025

Which intracellular enzyme is NOT upregulated in the presence of insulin? Glycogen phosphorylase Phosphofructokinase Lipoprotein lipase Pyruvate kinase Glucokinase

Which intracellular enzyme is NOT upregulated in the presence of insulin? Glycogen phosphorylase Phosphofructokinase Lipoprotein lipase Pyruvate kinase Glucokinase
Which intracellular enzyme is NOT upregulated in the presence of insulin?
Glycogen phosphorylase
Phosphofructokinase
Lipoprotein lipase
Pyruvate kinase
Glucokinase

Solution
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Answer

Glycogen phosphorylase Explanation 1. Identify the effect of insulin on enzymes Insulin generally upregulates enzymes involved in anabolic processes and downregulates those involved in catabolic processes. 2. Analyze each enzyme's role Glycogen phosphorylase is involved in glycogen breakdown (catabolic), thus not upregulated by insulin. Phosphofructokinase, pyruvate kinase, glucokinase are involved in glycolysis (anabolic) and lipoprotein lipase in fat storage (anabolic), all upregulated by insulin.

Explanation

1. Identify the effect of insulin on enzymes<br /> Insulin generally upregulates enzymes involved in anabolic processes and downregulates those involved in catabolic processes.<br /><br />2. Analyze each enzyme's role<br /> Glycogen phosphorylase is involved in glycogen breakdown (catabolic), thus not upregulated by insulin. Phosphofructokinase, pyruvate kinase, glucokinase are involved in glycolysis (anabolic) and lipoprotein lipase in fat storage (anabolic), all upregulated by insulin.
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