QuestionAugust 3, 2025

Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is a mutation in chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. What type of mutation occurs in the Philadelphia chromosome? A. duplication B. insertion C. inversion D. substitution E translocation

Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is a mutation in chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. What type of mutation occurs in the Philadelphia chromosome? A. duplication B. insertion C. inversion D. substitution E translocation
Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is a mutation in
chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a
malignancy. What type of mutation occurs in the Philadelphia chromosome?
A. duplication
B. insertion
C. inversion
D. substitution
E translocation

Solution
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Answer

E. translocation Explanation 1. Identify the type of mutation The Philadelphia chromosome involves an exchange of genetic material between chromosome 22 and chromosome 9, which is characteristic of a translocation.

Explanation

1. Identify the type of mutation<br /> The Philadelphia chromosome involves an exchange of genetic material between chromosome 22 and chromosome 9, which is characteristic of a translocation.
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