QuestionAugust 17, 2025

Which statement regarding adefovir is NOT correct? It inhibits HBV DNA polymerase. It has good oral bioavailability. It results in chain termination after incorporation. Dose reduction is required in renal dysfunction. It does not work against lamivudine -resistant strains of HBV.

Which statement regarding adefovir is NOT correct? It inhibits HBV DNA polymerase. It has good oral bioavailability. It results in chain termination after incorporation. Dose reduction is required in renal dysfunction. It does not work against lamivudine -resistant strains of HBV.
Which statement regarding adefovir is NOT correct?
It inhibits HBV DNA polymerase.
It has good oral bioavailability.
It results in chain termination after incorporation.
Dose reduction is required in renal dysfunction.
It does not work against lamivudine -resistant strains of HBV.

Solution
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Answer

It does not work against lamivudine-resistant strains of HBV. Explanation 1. Identify the mechanism of action Adefovir inhibits HBV DNA polymerase and results in chain termination after incorporation. 2. Evaluate oral bioavailability Adefovir has good oral bioavailability. 3. Consider dose adjustments Dose reduction is required in renal dysfunction due to its renal excretion. 4. Assess activity against resistant strains Adefovir works against lamivudine-resistant strains of HBV.

Explanation

1. Identify the mechanism of action<br /> Adefovir inhibits HBV DNA polymerase and results in chain termination after incorporation.<br /><br />2. Evaluate oral bioavailability<br /> Adefovir has good oral bioavailability.<br /><br />3. Consider dose adjustments<br /> Dose reduction is required in renal dysfunction due to its renal excretion.<br /><br />4. Assess activity against resistant strains<br /> Adefovir works against lamivudine-resistant strains of HBV.
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