QuestionJune 1, 2025

Mr. James Harris is undergoing treatment with natationmel (Tysabri) for multiple sclerosis Explain the role of nataltrumab in modulating the immune response se and its specific target. A. by binding to CO28. and migration by targeting alpha-4 integrins, reducing inflamination. C. Natabumab stimulates macrophage activity by promoting IL12 release. D. decreasing B-cell proliferation.

Mr. James Harris is undergoing treatment with natationmel (Tysabri) for multiple sclerosis Explain the role of nataltrumab in modulating the immune response se and its specific target. A. by binding to CO28. and migration by targeting alpha-4 integrins, reducing inflamination. C. Natabumab stimulates macrophage activity by promoting IL12 release. D. decreasing B-cell proliferation.
Mr. James Harris is undergoing treatment with natationmel (Tysabri) for multiple sclerosis Explain the role of nataltrumab in modulating the immune response se and its specific target.
A.	by binding to CO28.
and migration by targeting alpha-4 integrins, reducing inflamination.
C. Natabumab stimulates macrophage activity by promoting IL12 release.
D.	decreasing B-cell proliferation.

Solution
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Answer

B. Natalizumab inhibits leukocyte adhesion and migration by targeting alpha-4 Integrins, reducing inflammation. Explanation 1. Identify the Mechanism of Action Natalizumab is a monoclonal antibody that targets alpha-4 integrins. 2. Determine the Effect on Immune Response By binding to alpha-4 integrins, natalizumab inhibits leukocyte adhesion and migration across the blood-brain barrier, reducing inflammation in multiple sclerosis.

Explanation

1. Identify the Mechanism of Action<br /> Natalizumab is a monoclonal antibody that targets alpha-4 integrins.<br /><br />2. Determine the Effect on Immune Response<br /> By binding to alpha-4 integrins, natalizumab inhibits leukocyte adhesion and migration across the blood-brain barrier, reducing inflammation in multiple sclerosis.
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