QuestionAugust 17, 2025

Which enzyme is mainly responsible for the breakdown of statins? P450-3A4 CYP3A5 CYP2D6 CYP2C9 CYP1A2

Which enzyme is mainly responsible for the breakdown of statins? P450-3A4 CYP3A5 CYP2D6 CYP2C9 CYP1A2
Which enzyme is mainly responsible for the breakdown of statins?
P450-3A4
CYP3A5
CYP2D6
CYP2C9
CYP1A2

Solution
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Answer

P450-3A4 (CYP3A4) Explanation 1. Identify the enzyme responsible for statin metabolism Statins are primarily metabolized by the cytochrome P450 enzyme system, specifically **CYP3A4**.

Explanation

1. Identify the enzyme responsible for statin metabolism<br /> Statins are primarily metabolized by the cytochrome P450 enzyme system, specifically **CYP3A4**.
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