QuestionAugust 17, 2025

What most accurately describes the mechanism of action of tiagabine on gamma- aminobutyric acid (GABA)? GABA-B receptor antagonist GABA-B receptor agonist Inhibition of GAT-1 GABA-A receptor antagonist GABA-A receptor agonist

What most accurately describes the mechanism of action of tiagabine on gamma- aminobutyric acid (GABA)? GABA-B receptor antagonist GABA-B receptor agonist Inhibition of GAT-1 GABA-A receptor antagonist GABA-A receptor agonist
What most accurately describes the mechanism of action of tiagabine on gamma-
aminobutyric acid (GABA)?
GABA-B receptor antagonist
GABA-B receptor agonist
Inhibition of GAT-1
GABA-A receptor antagonist
GABA-A receptor agonist

Solution
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Answer

Inhibition of GAT-1 Explanation 1. Identify the Mechanism of Action Tiagabine works by inhibiting the reuptake of gamma-aminobutyric acid (GABA) into neurons and glia. 2. Determine the Specific Target It specifically inhibits the GABA transporter 1 (GAT-1), increasing GABA availability in the synaptic cleft.

Explanation

1. Identify the Mechanism of Action<br /> Tiagabine works by inhibiting the reuptake of gamma-aminobutyric acid (GABA) into neurons and glia.<br />2. Determine the Specific Target<br /> It specifically inhibits the GABA transporter 1 (GAT-1), increasing GABA availability in the synaptic cleft.
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