QuestionJuly 2, 2025

Listed below are steps from the sequence of excitation-contraction coupling in skeletal muscle cells. Select all the steps that are correct. Voltage-gated calcium channels open allowing calcium to enter the skeletal muscle cell from the extracellular fluid Myosin heads bind actin D Acetylcholine binds to nicotinic acetylcholine receptors resulting in sodium entering the cell. Voltage-gated calcium channels open to allow calcium into the SR An action potential is propagated along the muscle cell membrane and into T-tubules. Calcium binds to tropomyosin

Listed below are steps from the sequence of excitation-contraction coupling in skeletal muscle cells. Select all the steps that are correct. Voltage-gated calcium channels open allowing calcium to enter the skeletal muscle cell from the extracellular fluid Myosin heads bind actin D Acetylcholine binds to nicotinic acetylcholine receptors resulting in sodium entering the cell. Voltage-gated calcium channels open to allow calcium into the SR An action potential is propagated along the muscle cell membrane and into T-tubules. Calcium binds to tropomyosin
Listed below are steps from the sequence of excitation-contraction coupling in skeletal muscle
cells. Select all the steps that are correct.
Voltage-gated calcium channels open allowing calcium to enter the skeletal muscle cell from the
extracellular fluid
Myosin heads bind actin
D Acetylcholine binds to nicotinic acetylcholine receptors resulting in sodium entering the cell.
Voltage-gated calcium channels open to allow calcium into the SR
An action potential is propagated along the muscle cell membrane and into T-tubules.
Calcium binds to tropomyosin

Solution
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Answer

Acetylcholine binds to nicotinic acetylcholine receptors resulting in sodium entering the cell. ### An action potential is propagated along the muscle cell membrane and into T-tubules. ### Myosin heads bind actin. Explanation 1. Identify correct steps in excitation-contraction coupling Excitation-contraction coupling involves specific processes in skeletal muscle cells. Correct steps include: - Acetylcholine binds to nicotinic acetylcholine receptors resulting in sodium entering the cell. - An action potential is propagated along the muscle cell membrane and into T-tubules. - Myosin heads bind actin. 2. Exclude incorrect steps Incorrect steps are: - Voltage-gated calcium channels open allowing calcium to enter the skeletal muscle cell from the extracellular fluid (Calcium enters from the sarcoplasmic reticulum, not extracellular fluid). - Voltage-gated calcium channels open to allow calcium into the SR (Calcium is released from the SR, not entering it). - Calcium binds to tropomyosin (Calcium binds to troponin, not tropomyosin).

Explanation

1. Identify correct steps in excitation-contraction coupling<br /> Excitation-contraction coupling involves specific processes in skeletal muscle cells. Correct steps include:<br />- Acetylcholine binds to nicotinic acetylcholine receptors resulting in sodium entering the cell.<br />- An action potential is propagated along the muscle cell membrane and into T-tubules.<br />- Myosin heads bind actin.<br /><br />2. Exclude incorrect steps<br /> Incorrect steps are:<br />- Voltage-gated calcium channels open allowing calcium to enter the skeletal muscle cell from the extracellular fluid (Calcium enters from the sarcoplasmic reticulum, not extracellular fluid).<br />- Voltage-gated calcium channels open to allow calcium into the SR (Calcium is released from the SR, not entering it).<br />- Calcium binds to tropomyosin (Calcium binds to troponin, not tropomyosin).
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