QuestionAugust 17, 2025

What is the first-pass effect? Release of a drug's active ingredient from its formulation Drug metabolism in the liver before reaching systemic circulation Immediate drug effect upon first administration Initial drug distribution and plasma protein binding Complete drug elimination after first use

What is the first-pass effect? Release of a drug's active ingredient from its formulation Drug metabolism in the liver before reaching systemic circulation Immediate drug effect upon first administration Initial drug distribution and plasma protein binding Complete drug elimination after first use
What is the first-pass effect?
Release of a drug's active ingredient from its formulation
Drug metabolism in the liver before reaching systemic circulation
Immediate drug effect upon first administration
Initial drug distribution and plasma protein binding
Complete drug elimination after first use

Solution
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Answer

Drug metabolism in the liver before reaching systemic circulation Explanation 1. Define the first-pass effect The first-pass effect refers to the process where a drug is metabolized in the liver before it reaches systemic circulation. This can reduce the bioavailability of the drug.

Explanation

1. Define the first-pass effect<br /> The first-pass effect refers to the process where a drug is metabolized in the liver before it reaches systemic circulation. This can reduce the bioavailability of the drug.
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